Skip to Main Content

HRSA Electronic Handbooks

Funding Cycle View


Using Innovative Intervention Strategies to Improve Health Outcomes among People with HIV - Evaluation Center

  • Program Name:Special Projects of National Significance
  • Activity Code:U90
  • Application Available:12/18/2020
  • Application Deadline:3/8/2021
  • Created By:Schwab, Dawn
  • Created On:11/13/2019
  • Last Updated by:Wildberger, William
  • Last Updated On:12/18/2020
  • Estimated Project Start Date:8/1/2021

 Details of the changes posted in this announcement

Not Available

 Announcement Information

Announcement Number HRSA-21-068
Announcement Code
CFDA Number 93.928
Provisional No
Activity Code U90
Competitive Yes
Fiscal Year 2021


This notice announces the opportunity to apply for fiscal year 2021 (FY21) Health Resources and Services Administration (HRSA) Special Projects of National Significance (SPNS) Program funding for the initiative Using Innovative Intervention Strategies to Improve Health Outcomes among People with HIV – Evaluation Center. The purpose of this initiative is to use an implementation science framework1 to evaluate the pilot testing of innovative intervention strategies in four (4) focus areas at implementation sites subawarded through the companion cooperative agreement Using Innovative Intervention Strategies to Improve Health Outcomes among People with HIV – Coordinating Center (2iS CCTA; HRSA-21-076), and to disseminate the evaluation findings. HRSA will provide funding in the form of a cooperative agreement to support one (1) organization for up to four (4) years to serve as the Innovative Intervention Strategies Evaluation Center (2iS EC). The 2iS EC will develop and carry out a multi-site evaluation that includes a customized site-specific evaluation for each of the up to twenty (20) Ryan White HIV/AIDS Program (RWHAP)-funded recipients/subrecipients (approximately five sites per focus area) to serve as implementation sites where one intervention strategy per site will be piloted. In addition to the site-specific components, the evaluation will include cross-site components (e.g., costing, organizational assessments) that are consistent across all subawardee sites. Throughout this initiative, the 2iS EC will work closely with the 2iS CCTA, which will provide technical assistance to the subawardees. Ultimately, the 2iS EC’s evaluation findings will determine dissemination plans for the replication tools developed by the 2iS CCTA. Please review the companion funding opportunity announcement for more information on the role of the 2iS CCTA (HRSA-21-076). You may also review the previous initiative for which this is a competing continuation (HRSA-17-044; HRSA-17-049). 2iS Focus Areas This recipient will evaluate the implementation and associated health outcomes of three (3) priority populations and one (1) area of opportunity to improve service delivery for people with HIV. Combined, these four (4) focus areas are: 1) Improving HIV health outcomes for people with substance use disorder 2) Improving HIV health outcomes for lesbian, gay, bisexual, transgender, or queer (LGBTQ+) youth 3) Improving HIV health outcomes for people who are or have been incarcerated 4) Improving HIV health outcomes by using telehealth services 1 Psihopaidas D, Cohen SM, West T, et al. (2020) Implementation science and the Health Resources and Services Administration’s Ryan White HIV AIDS Program’s work towards ending the HIV epidemic in the United States. PLoS Med 17(11):e1003128. The 2iS EC will evaluate the uptake and integration of the intervention strategies as well as the associated client outcomes of these intervention strategies at the subawarded sites. Please review the related 2iS CCTA (HRSA-21-076) announcement to understand the collaborative work between the 2iS CCTA and the 2iS EC.

 Legislative Information

42 U.S.C. § 300ff-101 (§ 2691 of the Public Health Service Act)

 Application Information

Application Available 12/18/2020
Application Deadline 03/08/2021
Supplemental Application Deadline N/A
Explanation for Deadline N/A
Archive Date 05/07/2021
Letter of Intent Not required
Application Package SF424
Allow Applications to be Reopened in EHBs No
FOA Available Yes
Competitive Application Types Supported Continuation & Supplement
Allow Electronic Submission N/A
Page Limit for Application
Allow Multiple Applications
from an Organization from
Electronic Submission Instruction Electronic submission is/will be available in Grants.Gov

 General Information

Projected Award Date N/A
Estimated Project Period N/A
Estimated Project Start Date 08/01/2021
Estimated Project End Date 07/31/2025
Estimated Amount of this Competition $1,050,000.00
Estimated Number of Awards 1
Estimated Average Size of Awards $1,050,000.00
Cost Sharing No
Cooperative Agreement Yes

 Contact Information

Name Demetrios Psihopaidas, Ph.D., MA
Phone Number (301) 443-1469

 Download Information

Expand FOA (Guidance) Attachment (Maximum 1)
Document Name Size Date Attached Description
HAB HRSA-21-068 (U90) Final.pdf 509 kB 12/18/2020
Expand Application Package (Maximum 1)
No documents attached
Expand User Guide (Maximum 1)
No documents attached

Scroll to top