This Program Guidance solicits applications from the four Historically Black Colleges and Universities (HBCUs) that are specifically designated in statute to receive Centers of Excellence (COE) Program awards under Public Health Service Act (PHSA) section 736(c)(2). The COE Program funds innovative resource and education centers to assist health professions schools in supporting programs of excellence in health professions education for under-represented minority (URM) individuals. Specifically, the COE Program is part of a national strategy to improve the public’s access to quality, culturally appropriate health care by supporting programs that assist URM students and faculty