This notice solicits applications for the Quality Improvement in Newborn Screening Program. The purpose of this program is to improve the outcomes of newborns with conditions identified through newborn screening (NBS) by: 1) improving the amount of time it takes to identify infants at high risk for having one of these conditions; 2) improving the processes used for detecting out-of-range results; 3) improving the procedures for reporting out-of-range results to providers; 4) improving methods NBS programs use to confirm diagnoses; and 5) addressing emerging issues, or any other NBS process or procedure that could negatively affect the quality, accuracy, or timeliness of NBS.