This notice solicits applications for fiscal year (FY) 2018 for a new 3-year initiative entitled Evidence-Informed Approaches to Improving Health Outcomes for People Living with HIV (PLWH). The purpose of this program is to support a single organization that will systematically identify, catalog, disseminate, and support the replication of evidence-informed approaches and interventions to engage PLWH who are not receiving HIV health care (i.e., individuals who are not currently in care or have never been in care) or are at risk of not continuing to receive HIV health care.