This notice announces the opportunity to apply for funding under the Regional Telehealth Resource Center (RTRC) Program. RTRCs assist health care organizations, health care networks, and health care providers in the implementation of cost-effective telehealth programs to serve rural areas and populations. RTRCs also assist patients and families living in rural areas with telehealth technology to obtain health services. This notice of funding opportunity (NOFO) will support 12 RTRCs that focus on statewide and regional telehealth activities as shown below. RTRCs will serve as focal points for advancing the effective use of telehealth technologies in their respective communities and states.