This announcement solicits applications for a National Coordinating Center (NCC) to provide support for the Regional Genetics Networks (RGNs) in improving access to genetics services, with a particular emphasis on the medically underserved populations. The program aligns with the statutory authority for Special Projects of Regional and National Significance (SPRANS), Title V, § 501(a)(2) of the Social Security Act, as amended (42 U.S.C. 701 (a)(2)) that requires HRSA to provide “for genetic disease testing, counseling, and information development and dissemination programs.”