This notice solicits applications for a new three-year demonstration project entitled Improving Sexually Transmitted Infection Screening and Treatment for People Living with or at Risk for HIV. The purpose of this project is to support a single organization that will work collaboratively with Health Resources and Services Administration (HRSA) staff to promote clinical service and system-level interventions leading to an increase and/or improvements in the screening and treatment of sexually transmitted infections (STIs) among low-income people living with HIV (PLWH) or at risk for HIV who are served by HRSA’s Ryan White HIV/AIDS Program (RWHAP) and/or Health Center Program.